Colegio Argentino de Cardioangiólogos Intervencionistas Revista Argentina de Cardioangiología intervencionista 2250-7531 2313-9307 14 2 2023 06 30 Result of intrathrombus pharmacoinvasive endovascular treatment with forced infusion technique (pulse spray) and continuous infusion of streptokinase in patients with acute lower limb ischemia 0083 0086 EN David Parraga Meza Fellowship del Servicio de Hemodinamia y Cardioangiología Intervencionista. Hospital Municipal San José de Exaltación de la Cruz davidparragameza@hotmail.com Diego Martín Barbetta Fellowship del Servicio de Hemodinamia y Cardioangiología Intervencionista. Hospital Municipal San José de Exaltación de la Cruz M. Belén de Beus Fellowship del Servicio de Hemodinamia y Cardioangiología Intervencionista. Hospital Municipal San José de Exaltación de la Cruz Joaquín Etcheverre Médico Staff del Servicio de Hemodinamia y Cardioangiología Intervencionista. Hospital Municipal San José de Exaltación de la Cruz Pablo Nicolás Luna Jefe del Servicio de Hemodinamia y Cardioangiología Intervencionista. Hospital Municipal San José de Exaltación de la Cruz. Buenos Aires, Argentina In the year 2020, we began a study to understand the behavior of endovascular catheter-guided streptokinase as a treatment for acute lower limb ischemia. The aim was to evaluate its benefits, potential complications, and establish a protocol for its use as the initial treatment in patients arriving at our facility with this condition.The study included 8 patients who met the inclusion criteria. Catheter-directed fibrinolysis (CDT) was performed using two techniques combined: pulse spray and continuous infusion of streptokinase (STK) over a 12-hour period. The primary objective was to restore normal perfusion to the affected limb without causing endothelial trauma.At the conclusion of the study, based on the observed results, it was determined that this combined strategy of pulse spray and continuous infusion showed positive outcomes in the indicated patients with acute lower limb ischemia. Due to the accessibility and availability of STK compared to other scarce and more expensive fibrinolytics, this approach can be routinely adopted in our setting.Complications were minimal, and the success of the procedure not only relied on the chosen technique but also greatly depended on the patient's collaboration in adhering to the treatment and clinical follow-up. acute lower limb ischemia, catheter-directed thrombolysis, pulse spray thrombolysis, intrathrombus thrombolysis, streptokinase http://www.raci.com.ar/contenido/art.php?recordID=MjQzMA== http://recursos.meducatium.com.ar/contenido/articulos/31700830086_2430/pdf/31700830086.pdf