Colegio Argentino de Cardioangiólogos Intervencionistas Revista Argentina de Cardioangiología intervencionista 2250-7531 2313-9307 12 1 2021 03 31 Study of the utility of lorazepam in the prevention of radial spasm associated with coronary procedures 0044 0048 EN Ramiro Acevedo Servicio de Hemodinamia. Hospital ramiroacevedo_86@hotmail.com Raúl Solernó Servicio de Hemodinamia. Hospital Pablo Pedroni Servicio de Hemodinamia. Hospital Noelia Saaby Servicio de Hemodinamia. Hospital José Milanesi Servicio de Hemodinamia. Hospital Diego Grinfeld Servicio de Hemodinamia. Hospital Martín Oscos Servicio de Hemodinamia. Hospital Agustín Hauqui Servicio de Hemodinamia. Hospital Federico Giachello Servicio de Hemodinamia. Hospital Ricardo Aquiles Sarmiento Servicio de Hemodinamia. Hospital Introduction. The radial route is the access of choice in most parts of the world to perform coronary diagnostic and therapeutic procedures thanks to its better safety profile compared to the femoral access, lower in-hospital costs, and greater comfort for the patient. Its use has not quite been imposed in certain regions of the world. Its main disadvantage is vasospasm. Sometimes, this phenomenon negatively conditions the use of this access and the femoral access ends up being the option here. This prospective, randomized, and double-blind study included a primary endpoint where we intended to assess the efficacy and safety profile of sublingual lorazepam to reduce the rate of radial spasm in coronary diagnostic and therapeutic procedures compared to placebo. The secondary endpoint was given by the rate of complications seen between the two groups.Results. Appearance of clinical spasm: 31.03% vs. 28.73% (OR=1.11 (0.58-2.13) p=0.74); technical spasm: 13.79% vs. 13.79%, (OR=1 (0.42-2.36) p=1); angiographic spasm: 56.32% vs. 47.12%, (OR=1.44 (0.79-2.62) p: 0.22) for groups A and B, respectively. Conversion to the femoral access: group A: 3.44% vs. group B: 6.89% (OR=0.48 (0.11-1.99) p=30). No differences were seen in the rate of complications between the two groups.Conclusion. The administration of sublingual lorazepam prior to admission to the cath lab does not reduce radial spasm compared to placebo when this access is used to perform coronary diagnostic and/or therapeutic procedures. No significant differences were seen either in the rate of complications between the two groups. lorazepam, spasm, radial artery http://www.raci.com.ar/contenido/art.php?recordID=MTkwOQ== http://recursos.meducatium.com.ar/contenido/articulos/25400440048_1909/pdf/25400440048.pdf